NSI 189 FOR SALE, BENEFITS, REVIEW and DOSAGE
NSI-189 PHOSPHATE BENEFITS:
- haults depression symptoms
- Enhances plasticity
- Decreases mental confusion
- Reduces symptoms of major depression
- Aids in age-related mental decline
- Alleviates symptoms of diabetic neuropathy
- Fast recovery from ischemic stroke (brain injury stroke)
- Assists with motor recovery from Angelman Syndrome
- Neuroprotection from brain injury or irradiation-induced damage
- Expanded memory in Alzheimer's disease
- significant improvements within restoring brain cells
NSI-189 is in the group of nootropic chemicals. The term 'nootropics' primarily portrayed chemicals with meticulous criteria, however now it describes any natural or synthetic substance which might positively affect our psychological abilities, especially retention and intellect.
NSI-189 is an experimental neurogenic compound. It may treat MDD (Major Depressive disorder), stroke, cognitive impairment, traumatic brain injury, and age-related neurodegeneration.
NSI189 is a benzylpiperazine-aminopyridine, a unique chemical body.
NSI supplies neurogenesis to the hippocampus and accelerates the neural stem cells.
NSI 189 phosphate is a novel neurogenic molecule with properties where a single gene's production occurs from two or more unrelated effects.
It includes antidepressant qualities, reduces mental confusion, improves synaptic plasticity, and neurotrophic activities demonstrated in preclinical studies.
Synaptic plasticity has two general forms. Intrinsic and extrinsic. Intrinsic mechanisms have to do with changes in the strength of a synapse occurring from its activity. Extrinsic plasticity has to do with a change in the strength of a synapse brought about by activity in a different pathway.
Its antidepressant activity is monoamine-independent. NSI-189 was previously tested in patients with recurrent major depressive disorder in clinical trials in an inpatient setting.
NSI-189 is especially beneficial in Major depressive disorder (MDD), a mental disorder characterized by all-encompassing low mood episodes, accompanied by depressed self-esteem and loss of attention or enjoyment in normally pleasant events. MDD is the prominent cause of disability in the United States (U.S.) for persons age 15 to 44.
The compound was discovered by systematically screening a chemical library against the in vitro model of HI neurogenesis using a stable cell line of human fetal HI neural stem cells (US Pat. No. 8,293,488; 7,650,533).
NSI-189 is a new, neurogenic compound independent of serotonin or norepinephrine reuptake inhibition of pathways.
HOW DOES NSI-189 AFFECT MY BRAIN
It raises the hippocampal level like other antidepressants. Although what sets it apart is its ability to screen for compounds responsible for the increase among rodents.
The hippocampus is liable for consolidating information from short-term memory to long-term memory and spatial navigation.
NSI-189 has been demonstrated to stimulate neurogenesis of human hippocampus-derived neural stem cells in vitro and in vivo.
Two hundred and twenty human subjects were randomized to NSI-189 40 mg daily, 80 mg daily, or placebo for 12 weeks. The primary outcome measure was the Montogmery Asberg Depression Rating Scale (MADRS).
IS NSI-189 SAFE?
Doses appeared to be well-tolerated. These findings replicate those of the phase 1b study and warrant further exploration of the antidepressant and pro-cognitive effects of NSI-189.
A study on rats resulted in enhanced brain and motor discrepancies after a stimulating stroke. NSI-189 overturns cell death that is caused by oxygen deprivation. The effect lasted 24 weeks.
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For anyone wanting to increase their cognitive function, some doctors believe the right nootropics can help you think clearly and sharply, as well as reducing age-related cognitive decline.
NSI-189 offers an essential chance for a distinguished healing agent, exceptionally one that may act through a novel structure of action with few side effects.
IUPAC name: (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]methanone
CAS Number: 1270138-40-3
Molecular Formula: C22H33N4O5P
Molar Mass: 366.5 g/mol