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TIANEPTINE SODIUM BENEFITS
- Anxiolytic effects
- Neuronal remodeling
- Reduces stress-induced atrophy of neuronal dendrites
- Restores neuronal metabolism and function
- Fully agonize both mu- and delta-opioid receptors.
- ADHD treatment
- Fibromyalgia pain treatment
TIANEPTINE SODIUM REVIEW
Tianeptine is the generic brand name of Stablon and Coaxial, among a few others. It is an atypical anti-depressant compound that is primarily used in the treatment of Major Depressive Disorder. It has similarly been used for the treatment of asthma, irritable bowel syndrome, and anxiety. Tianeptine is comparable to amitriptyline, imipramine, and fluoxetine but with significantly fewer side effects.
IS TIANEPTINE LEGAL?
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TIANEPTINE TREATMENT FOR ASTHMA?
Tianeptine has been described to be very effective for asthma. tianeptine was the only agent known to reduce free serotonin in plasma and enhance uptake in platelets; November 2004, there had been two double-blind placebo-controlled crossover trials and a >25,000 person open-label study lasting more than seven years, all showing effectiveness
Fibromyalgia and ADHD?
Tianeptine also has anticonvulsant, analgesic effects, and a clinical trial in Spain that ended in January 2007 has shown that tianeptine effectively treats pain due to fibromyalgia. Tianeptine has been shown to have effectiveness with minimal side effects in the treatment of attention-deficit hyperactivity disorder.
TIANEPTINE FOR DEPRESSION
Tianeptine has anti-depressant and anxiolytic effects with a reasonable shortage of sedative, anticholinergic, and cardiovascular side effects. It has been discovered to act as an atypical agonist of the opioid receptor with clinically minor effects on the δ- and κ-opioid receptors, as do most tricyclic anti-depressants.
Research suggests that tianeptine produces its anti-depressant effects through indirect alteration and inhibition of glutamate receptor activity (i.e., AMPA receptors and NMDA receptors) and release of BDNF, in turn affecting neural plasticity. Some researchers hypothesize that tianeptine has a protective effect against stress-induced neuronal remodeling.
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IUPAC name 7-[(3-Chloro-6-methyl-5,5-dioxo-11H-benzo[c][2,1]benzothiazepin-11-yl)amino]heptanoic acid
CAS number 72797-41-2
Molar mass 436.95 g·mol−1